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A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)

Forcano Gamazo, Laura; Soldevila-Domenech, Natalia; Boronat, Anna; Sánchez-Benavides, Gonzalo Andrés; Puig-Pijoan, Albert; Lorenzo, Thais; Aldea-Perona, Ana; Suárez-Calvet, Marc; Cuenca Royo, Aida; Gispert, Juan Domingo; Gomis-Gonzalez, Maria; Minguillon, Carolina; Diaz-Pellicer, Patricia; Fauria, Karine; Piera, Iris; Langohr, Klaus; Dierssen, Mara; Pizarro Lozano, Nieves; Mur, Esther; Grau-Rivera, Oriol; de la Torre, Rafael (The Journal of Prevention of Alzheimer's Disease. 2025 Sep;12(8):100271, 2025-09)

Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. ...