Listando por materia "Chronic pain"

Mostrando ítems 1-2 de 2

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

Vidal-Torres, Alba; Fernandez Pastor, Begoña; García López, Mónica; Ayet Galcerà, Eva; Cabot, Anna; Burgueño, Javier; Monroy, Xavier; Aubel, Bertrand; Codony, Xavier; Romero, Luz; Pascual, Rosalía; Serafini, MªTeresa; Encina, Gregorio; Almansa, Carmen; Zamanillo, Daniel; Merlos, Manuel; Vela, José Miguel (Acta Pharmaceutica Sinica B. 2023;13(1):82-99, 2023)

Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) ...
Ultrasound-guided gluteal nerves electrical stimulation to enhance strength and power in individuals with chronic knee pain: a randomized controlled pilot trial

Sartori, Francesco; Flores Fagnani, Pedro Luiz; Monné Guasch, Laia; La Cagnina, Giovanni; Picañol, Javier; Puig-Diví, Albert (Frontiers in Medicine. 2024 Jul;11:1410495, 2024-07)

Introduction: Various pathophysiological contexts can be accompanied by weakness, arthrogenic muscle inhibition, and even disability. In this scenario, peripheral nerve stimulation has been studied not ...