A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)

Forcano Gamazo, Laura; Soldevila-Domenech, Natalia; Boronat, Anna; Sánchez-Benavides, Gonzalo Andrés; Puig-Pijoan, Albert; Lorenzo, Thais; Aldea-Perona, Ana; Suárez-Calvet, Marc; Cuenca Royo, Aida; Gispert, Juan Domingo; Gomis-Gonzalez, Maria; Minguillon, Carolina; Diaz-Pellicer, Patricia; Fauria, Karine; Piera, Iris; Langohr, Klaus; Dierssen, Mara; Pizarro Lozano, Nieves; Mur, Esther; Grau-Rivera, Oriol; de la Torre, Rafael; Forcano Gamazo, Laura; Soldevila-Domenech, Natalia; Boronat, Anna; Sánchez-Benavides, Gonzalo Andrés; Puig-Pijoan, Albert; Lorenzo, Thais; Aldea-Perona, Ana; Suárez-Calvet, Marc; Cuenca Royo, Aida; Gispert, Juan Domingo; Gomis-Gonzalez, Maria; Minguillon, Carolina; Diaz-Pellicer, Patricia; Fauria, Karine; Piera, Iris; Langohr, Klaus; Dierssen, Mara; Pizarro Lozano, Nieves; Mur, Esther; Grau-Rivera, Oriol; de la Torre, Rafael

doi:10.1016/j.tjpad.2025.100271

Abstract

Background: The potential of dietary compounds to enhance the effects of multimodal lifestyle interventions (MLIs) on cognition in individuals at high risk of cognitive impairment remains unclear. Objectives: To assess whether the addition of a green tea extract enriched with epigallocatechin-3-gallate (EGCG) enhances the effects of an MLI. Design: Double-blind, randomized, two-arm, and placebo-controlled trial. Exploratory comparisons were made with a non-randomized group (NRG) receiving healthy lifestyle recommendations. Setting: Population-based study conducted in Barcelona, Spain. [...]